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@article{205630,
        author = {Shubam Sharma and Prof. Vinayak Munde},
        title = {Gastroretentive Floating Drug Delivery Systems: Recent Advances and Applications in Antihypertensive Therapy},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {7176-7186},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=205630},
        abstract = {Hypertension remains one of the leading causes of cardiovascular morbidity and mortality worldwide, necessitating effective and sustained pharmacological management. Conventional oral dosage forms of antihypertensive drugs often exhibit limitations such as short gastric residence time, variable absorption, frequent dosing, and fluctuating plasma drug concentrations, which may compromise therapeutic efficacy and patient compliance. Gastroprotective Floating Drug Delivery Systems (GFDDS) have emerged as a promising approach to overcome these challenges by prolonging gastric residence time and providing controlled drug release. These systems remain buoyant in the gastric environment for extended periods, allowing sustained drug delivery in the upper gastrointestinal tract where absorption is often optimal. Recent advances in polymer science, formulation technologies, nanotechnology, and multifunctional gastroprotective systems have significantly enhanced the performance of floating drug delivery systems. Several antihypertensive drugs, including propranolol, atenolol, carvedilol, metoprolol, verapamil, and diltiazem, have been successfully incorporated into floating formulations to improve bioavailability, reduce dosing frequency, and maintain therapeutic plasma concentrations. This review discusses the principles, classification, mechanisms, formulation approaches, evaluation parameters, recent technological advancements, and applications of gastroretentive floating drug delivery systems in antihypertensive therapy. Furthermore, future prospects and challenges associated with the development of advanced gastroretentive systems are highlighted.},
        keywords = {Gastroretentive drug delivery system, Floating drug delivery system, Antihypertensive drugs, Controlled release, Gastric retention, Bioavailability enhancement.},
        month = {June},
        }