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@article{205767,
        author = {Indrayani Satpute and Prof. Vinayak Munde},
        title = {Pulsatile Drug Delivery: Principles, Technologies, and Therapeutic Applications},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {7826-7835},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=205767},
        abstract = {Pulsatile drug delivery systems (PDDS) represent an advanced approach to controlled drug delivery designed to release therapeutic agents after a predetermined lag time or in response to physiological or external stimuli. Unlike conventional sustained-release formulations that maintain relatively constant plasma drug concentrations, pulsatile systems are developed to synchronize drug release with the body's circadian rhythms and disease-specific biological cycles. Such systems are particularly beneficial in diseases exhibiting time-dependent pathophysiology, including asthma, hypertension, rheumatoid arthritis, diabetes mellitus, peptic ulcer disease, attention-deficit hyperactivity disorder, and cardiovascular disorders. This review comprehensively discusses the fundamental principles of pulsatile drug delivery, chronobiological concepts underlying chronotherapeutic, classification of pulsatile systems, formulation technologies, mechanisms of drug release, evaluation methods, marketed products, therapeutic applications, recent technological advances, regulatory aspects, current challenges, and future perspectives. Furthermore, emerging trends involving artificial intelligence, additive manufacturing, personalized medicine, and stimuli-responsive biomaterials are highlighted as promising strategies for the next generation of pulsatile drug delivery systems.},
        keywords = {Pulsatile drug delivery, Chronotherapy, Chrono pharmacology, Circadian rhythm, Controlled drug delivery.},
        month = {June},
        }