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@article{206500,
        author = {Shital Vijay Sirsat and Shital Dhanmane and Rutuja Kakad and Swapnil Sanap},
        title = {FORMULATION AND EVALUATION OF POLYMERIC NANOPARTICLES OF NIFEDIPINE FOR ENHANCED SOLUBILITY, DISSOLUTION AND ORAL BIOAVAILABILITY},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {2},
        pages = {1782-1789},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=206500},
        abstract = {The present study focused on the development and evaluation of polymeric nanoparticles of nifedipine to enhance its solubility, dissolution rate, stability, and oral bioavailability. Nifedipine, a poorly water-soluble antihypertensive drug belonging to Biopharmaceutics Classification System (BCS) Class II, exhibits low bioavailability owing to poor aqueous solubility. To overcome this limitation, polymeric nanoparticles were prepared by the ionic gelation (ionotropic gelation) method using chitosan and sodium alginate as biodegradable polymers and sodium tripolyphosphate (TPP) as a cross-linking agent. Eight nanoparticle batches (F1-F8) were evaluated for particle size, polydispersity index (PDI), zeta potential and drug entrapment efficiency; Fourier Transform Infrared (FTIR) spectroscopy confirmed drug-excipient compatibility, and Differential Scanning Calorimetry (DSC) indicated retention of drug crystallinity. The optimized nanoparticle batch (F6) was incorporated into Tablets (F1-F7) and evaluated for pre- and post-compression parameters including thickness, hardness, weight variation, friability, drug content, disintegration time and in vitro drug release. Batch F4 exhibited the maximum cumulative drug release (98.6 ± 0.4% at 12 h) with acceptable mechanical and stability characteristics, and was selected as the optimized formulation. Stability studies conducted as per ICH guidelines confirmed that the optimized formulation remained sTable over a three-month period. The study concludes that a polymeric nanoparticle-based drug delivery system markedly improves the dissolution rate and therapeutic performance of poorly soluble drugs such as nifedipine and represents a promising strategy for oral antihypertensive therapy.},
        keywords = {Nifedipine; Polymeric Nanoparticles; Ionotropic Gelation; Chitosan; Sodium Alginate; Sustained Release; Bioavailability Enhancement; Drug Delivery System; Dissolution Rate; BCS Class II.},
        month = {July},
        }