ADVANCED STUDY ON ANTICONVULSANT DRUGS & IT'S SCREENING MODELS
Author(s):
Pratiksha S. Surwase, Irshad A.Shaikh, Nandkishor B. Bavage, Vidyasagar Gali, Shyamlila B. Bavage
Keywords:
Anticonvulsant drug, Classification, Mechanism, Treatment and diagnosis
Abstract
The word “Fit “is sometimes used to mean convulsion or epileptic seizures. A sudden violent, irregular movement of the body caused by involuntary contraction of muscles of associated especially with brain disorder such as epilepsy, the presence of certain toxins or other agents in the blood or fever in childrens. Anticonvulsants are diverse group of pharmacological agents used in the treatment of epileptic seizure also used in the treatment of bipolar disorder and borderline personality disorder. Epilepsy has been considered as a public health problem by WHO and ILAE. The American Academy of Neurology (AAN), representing over 20,000 Neurologist and Neuroscience professionals, has taken an active interest in clinical, ethical and policy considerations. The AAN opposes generic substitution of Anticonvulsant drug for the treatment of epilepsy without attending physicians approval. The action of clinically used Anticonvulsant drugs on sustained high frequency repetitive firing of action potentials and on responses to GABA have been determined using mouse neurons in cell culture and classification Anticonvulsant drugs action have been developed in three categories based on these cellular mechanism of action: 1. Phenytoin, Carbamazepine and Valproic acid. 2.Phenobarbital, Benzodiazepines, Clonazepam, Diazepam, Nitrazepam. 3. Ethosuximide. In Novel Anticonvulsant Drug different aspects of new anticonvulsant drug (2nd generation) from preclinical and clinical testing, pharmacokinetics and mono or combination therapy in children and adult are summarized. Important data concerning the effect and tolerability of Anticonvulsant drug, can be obtained from controlled studies. Thus article will also provide review of selected anticonvulsant, focusing on drugs most likely to control seizure in small animals. The influence of aging on the activity of 5 Anticonvulsant agent was studied in rat and mice. The mechanism, these drug classified according to their action on sustained high frequency repetitive firing (SRF) of action potentials and GABA responses and in diagnosis some test are discuss, treatment against the convulsion includes the anti seizure medications, surgery and other therapies. In this article, the Anticonvuls
Article Details
Unique Paper ID: 149357

Publication Volume & Issue: Volume 6, Issue 12

Page(s): 107 - 114
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Last Date 25 August 2020

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