Detecting Composite Functional Module in miRNA Regulation and mRNA Interaction Network
Author(s):
Sakshi Sharma, Sangmeshwar Yewange, Ms. Shweta Tyagi, Dr.Abhimanyu Kumar Jha
Keywords:
miRNA-mRNA regulatory modules, Collective group relationships, Group pair, Canonical correlations
Abstract
MicroRNAs (miRNAs) play an essential role in the post-transcriptional gene regulation in plants and animals. They regulate a wide range of biological processes by targeting messenger RNAs (mRNAs). Evidence suggests that miRNAs and mRNAs interact collectively in gene regulatory networks. The collective relationships between groups of miRNAs and groups of mRNAs may be more readily interpreted than those between individual miRNAs and mRNAs, and thus are useful for gaining insight into gene regulation and cell functions. Several computational approaches have been developed to discover miRNA-mRNA regulatory modules (MMRMs) with a common aim to elucidate miRNA-mRNA regulatory relationships. However, most existing methods do not consider the collective relationships between a group of miRNAs and the group of targeted mRNAs in the process of discovering MMRMs. Our aim is to develop a framework to discover MMRMs and reveal miRNA-mRNA regulatory relationships from the heterogeneous expression data based on the collective relationships.
Article Details
Unique Paper ID: 152105

Publication Volume & Issue: Volume 8, Issue 2

Page(s): 321 - 325
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