ACTIGRAPHY MONITORING OF SYMPTOMS IN PATIENTS WITH PARKINSON'S DISEASE

Bidve Nisha; Jadhav Rohini; Pratiksha Shinde; Renuka R. Deshpande

ACTIGRAPHY MONITORING OF SYMPTOMS IN PATIENTS WITH PARKINSON'S DISEASE

Authors: Bidve Nisha, Jadhav Rohini, Pratiksha Shinde, Renuka R. Deshpande

Unique Paper ID: 149652
Volume: 7
Issue: 1
PageNo: 213-218

Keywords: Actigraphy Parkinson's disease Power-law exponent

Abstract:
Although the Unified Parkinson's Disease Rating Scale (UPDRS) is the â€œgold-standardâ€ tool in assessing the severity of symptoms in patients with Parkinson's disease (PD), not all activity-related disease symptoms can be accurately captured by the well-established clinical rating scale. Using an alternative approach, this study examined the level of physical activity measured by actigraphy over time and whether change in physical activity was associated with disease severity assessed by UPDRS. We used a longitudinal design in which physical activity and disease severity were assessed repeatedly during a 4-month interval, over a 3-year observational period, in a sample of 61 patients with idiopathic PD and a control group of 32 neurologically intact individuals. Physical activity data during awake-time were analyzed using the power-law exponent (PLE) method. Correlational relationships between changes in maxima values of PLE and scores of total UPDRS, UPDRSâ€”part II (Activities of Daily Living), and UPDRSâ€”part III (Motor Examination) in patients with PD were examined. Results show an increase in maxima values of PLE and the UPDRS total score in PD patients and that there is a positive association between changes in maxima values and total UPDRS score (r=0.746, p=0.032), UPDRSâ€”part II score (r=0.687, p=0.027), and UPDRSâ€”part III score (r=0.893, p=0.018). There was no significant change in the level of physical activity over time for the controls. Findings from this study indicate that change in physical activity, as captured by actigraphy, is associated with increased severity in patients' clinical symptoms of PD over time. Thus, these data suggest that, when used in conjunction with the conventional UPDRS measure, an actigraphic measure of physical activity may provide clinicians an adjunct measurement approach to monitor patients' activity-based disease progression or responses to treatment in outpatient clinic settings.

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Cite This Article

ISSN: 2349-6002
Volume: 7
Issue: 1
PageNo: 213-218

ACTIGRAPHY MONITORING OF SYMPTOMS IN PATIENTS WITH PARKINSON'S DISEASE

Available:https://ijirt.org/Article?manuscript=149652

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