INSULIN-LIKE GROWTH FACTOR AND PROSTATE CANCER RISK

Surajkumar Shivajirao Choukate; Shyamlila B. Bavage; Nandkishor B. Bavage

INSULIN-LIKE GROWTH FACTOR AND PROSTATE CANCER RISK

Authors: Surajkumar Shivajirao Choukate, Shyamlila B. Bavage, Nandkishor B. Bavage

Unique Paper ID: 152365
Volume: 8
Issue: 3
PageNo: 31-38

Keywords: prostate cancer insulin-like growth factor; insulin-like growth factor binding protein meta-analysis.

Abstract:
Insulin-like growth factors (IGF-I, IGF-II) and their binding proteins (IGFBP-1â€“6) important role in cell proliferation, differentiation and apoptosis, suggesting possible involvement in carcinogenesis. Several epidemiological studies show the associations of IGFs with prostate cancer .We searched the published literature for all studies related with the levels of IGFs with prostate cancer. We performed random effects meta-analysis to calculate the summary odd ratios. The number of studies (prostate cancer cases) included in each meta-analysis were 42 (7,481) IGF-I; 10 (923) IGF-II; 3 (485) IGFBP-1; 5 (577) IGFBP-2; 29 (6,541) IGFBP-3 and 11 (3,545) IGF-1: IGFBP-3 ratio. The pooled odds ratios (95%confidence intervals) per standard deviation increase in peptide were: IGF-I, OR 5 1.21 (1.07, 1.36); IGF-II, OR 5 1.17(0.93,1.47) IGFBP-1, OR 5 1.21 (0.62, 2.33); IGFBP-2, OR 5 1.18 (0.90, 1.54); IGFBP-3, OR 5 0.88 (0.79, 0.98); IGFI:IGFBP-3 ratio, OR 5 1.10 (0.97, 1.24).There was weak evidence that associations of the IGF-I and IGFBP-3 with prostate cancer were stronger for the advanced disease. Our meta-analysis confirms that the raised circulating lGF-I is positively associated with prostate cancer risk.

Download article

email to a friend

Cite This Article

ISSN: 2349-6002
Volume: 8
Issue: 3
PageNo: 31-38

INSULIN-LIKE GROWTH FACTOR AND PROSTATE CANCER RISK

Available:https://ijirt.org/Article?manuscript=152365

09 Nov, 2021

REVIEW ON DIABETES MELLITUS

17 Oct, 2021

DRUG REPURPOSING IN ANTIVIRAL RESEARCH: A REVIEW

08 Aug, 2021

RHINO-ORBITAL MUCORMYCOSIS ASSOCIATED WITH COVID-19

08 Aug, 2021

THE PRINCIPLES OF SKIN TISSUE ENGINEERING

08 Aug, 2021

A REVIEW ON LYME BORRELIOSIS

31 Jul, 2021

AWARENESS ABOUT BANNED DRUG

31 Jul, 2021

APPLICATION AND THE PRODUCTION OF RADIOPHARMACEUTICAL’S

30 Jul, 2021

ANTHELMINTIC ACTIVITY OF SOME MEDICINAL PLANTS

30 Jul, 2021

A REVIEW ON DRUMSTICK PLANTS (MORINGA OLEIFERA) MEDICAL USES AND NUTRITIONAL PROPERTIES

29 Jul, 2021

PHARMACOTHERAY OF HYPERTENSION

Impact Factor
8.01 (Year 2024)

UGC Approved
Journal no 47859

Join Our IPN

IJIRT Partner Network

Submit your research paper and those of your network (friends, colleagues, or peers) through your IPN account, and receive 800 INR for each paper that gets published.

Join Now

Latest Publication

Recent Conferences

NCSEM 2024

National Conference on Sustainable Engineering and Management - 2024 Last Date: 15th March 2024

Submit inquiry