TRADITIONAL HERBAL MEDICINE AGAINST CAGA AND VACA TOXIN GENES-PRODUCING DRUG RESISTANT HELICOBACTER PYLORI
Author(s):
Kiran. A. Birajdar, Shyamlila B. Bavage, Nandkishor B. Bavage
Keywords:
Abstract
Pan-Drug Resistant (PDR), Helicobacter pylori remains an unparalleled challenge to public health worldwide and this is largely due to the presence of the A-associated cytotoxin type A (CagA) and release of cytotoxin A (VacA). On the other hand, plant plants such as Syzygium aromatic contains various types of secondary metabolites, which can be used to fight H.pylori germs. To our knowledge, this is the first biomedical energy report of Aromatic extract against the cytotoxin-associated genes that produce PDR H. pylori. In this study, out of 45 gastral antral biopsy examples of patients with dyspeptic, 20 cases were confirmed as H. pylori. Eight (40%) out of 20 constipation was PDR H. pylori while other complications were Multi-Drug Resistant (MDR) types. Genotypic analysis of PDR H. pylori viruses showed that the genes of cagA and vacA were found in 75% and 87.5%, respectively and m2s2 was the most common subtype of the vacA gene. S. aromatic showed very high anti-H. pylori compared to Cinnamomum zeylanicum and Tymus vul- garis. Eugenol was the largest phenolic compound (28.14%) found in the methanolic extract of S. aromaticum. Clearly, the results of the toxicity test confirmed the safety of S. aromaticum of use. Therefore, these results suggest that S.Aromaticum may be a new and effective antimicrobial agent unable to fight the cytotoxin genes that produce the drug H. pylori. Moreover, these the findings provide a scientific basis for the development of antimicrobial agents from traditional remedies anti-inflammatory drugs against gastric ulcer.
Article Details
Unique Paper ID: 152392

Publication Volume & Issue: Volume 8, Issue 3

Page(s): 183 - 188
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