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FORMULATION AND EVALUATION OF PRESS-COATED PULSATILE DELIVERY OF FLURBIPROFEN TABLETS

  • Unique Paper ID: 152644
  • Volume: 8
  • Issue: 3
  • PageNo: 1021-1025
  • Abstract:
  • The objective of present study is to formulate and evaluation of press-coated pulsatile delivery of flurbiprofen tablets for treatment of rheumatoid arthritis. The press coated method to mimic the circadian rhythm of the disease by releasing the drug with a distinct predetermined lag time of 4 hours. The design of the system consists of a rapid release core and controlled release coat. A combination of HPMC K 15M and eudragit RL 100, was used as a coating material for the tablet. The formulations (F1-F3) of the core were prepared by using crospovidone (CP) as disintegrants in different proportions (10%, 15% and 20%) to study the effect of variable concentrations of these on the characteristics of the formulation. Among these formulations, F1 containing CP (20%) as disintegrant showed a better drug release of 98% over 1hr was selected. The core was coated with of HPMC K 15M and eudragit RL100 with different polymer ratios (F1- F6). Among these, F6 was optimized formulation based on the lag time and percent of drug release (96% of drug release in 6 hours). Thus, compression coated tablets with a clear lag time before drug release is a potentially useful formulation for the treatment of rheumatoid arthritis.
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Cite This Article

  • ISSN: 2349-6002
  • Volume: 8
  • Issue: 3
  • PageNo: 1021-1025

FORMULATION AND EVALUATION OF PRESS-COATED PULSATILE DELIVERY OF FLURBIPROFEN TABLETS

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8.01 (Year 2024)
UGC Approved
Journal no 47859

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