An Updated Review Article on Simultaneous Determination of Paracetamol and Ibuprofen in Tablets by RP-HPLC Method

An Updated Review Article on Simultaneous Determination of Paracetamol and Ibuprofen in Tablets by RP-HPLC Method
Author(s):
Rushikesh Nanaware, Seema Gosavi
Keywords:
Paracetamol, Validation, Dosage Form, Ibuprofen, Estimation
Abstract
For the analysis of paracetamol and ibuprofen, a straightforward, precise, high performance liquid chromatographic (HPLC) approach was created and validated. Use Inertsil C18, 5, 150 mm x 4.6 mm for the C18 column. A mobile phase of acetonitrile/phosphate buffer (60:40, v/v, pH 7.0) was used, and the separation was carried out isocratically with UV detection at 260 nm. The internal standard was aceclofenac. Ibuprofen, paracetamol, and aceclofenac had retention times of 2.48, 4.45, and 6.34 minutes, respectively. - Column temperature 25 °C, Mobile Phase Flow: 1 mL / min .The new method's accuracy, precision, linearity, limit of detection, and limit of quantitation were all validated. This work sought to create and validate an HPLC method that is straightforward, precise, and picky. The suggested approach can be utilized for the determination of these drugs in combined dosage forms.
Article Details
Unique Paper ID: 159034 Publication Volume & Issue: Volume 9, Issue 11 Page(s): 145 - 150
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