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@article{189107,
        author = {Devika Bhuva and Anup Thakar},
        title = {Humanin Biomarker and Its Conceptual Relationship with Diabetes Mellitus (Prameha): An Integrative Review},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {4716-4719},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=189107},
        abstract = {Diabetes Mellitus (DM), a global metabolic disorder, is characterized by impaired glucose regulation, insulin resistance, and progressive tissue damage. In Ayurveda, this condition is described as Prameha, a group of disorders arising from dosha imbalance, dhatu vitiation (dhatu dushti) and weakened digestive/metabolic fire (agni). Modern biomedical research has identified Humanin, a mitochondria-derived peptide, as a novel biomarker with significant implications for metabolic health. Humanin exerts cytoprotective effects through anti-apoptotic, anti-inflammatory, and antioxidative mechanisms, while enhancing insulin sensitivity and glucose homeostasis. These functions conceptually align with Ayurvedic principles of maintaining equilibrium among doshas and preserving tissue integrity. This integrative review synthesizes contemporary molecular insights on Humanin with classical Ayurvedic frameworks. Humanin’s role in preventing cellular apoptosis parallels Ayurvedic emphasis on protecting dhatus from depletion. Its regulation of insulin signalling and lipid metabolism corresponds to Ayurvedic understanding of kapha and meda dhatu imbalances. Furthermore, its antioxidative and anti-inflammatory actions mirror Ayurvedic strategies to mitigate pitta aggravation and oxidative stress. By mapping these biological functions to traditional concepts, Humanin emerges as a molecular correlate of Ayurvedic protective mechanisms. The review also highlights Humanin’s potential as a biomarker for early detection, disease progression monitoring, and therapeutic targeting in DM. Compared to conventional markers such as HbA1c and fasting glucose, Humanin offers unique insights into mitochondrial health and systemic resilience. Its therapeutic promise lies in Humanin analogy and peptide-based interventions, which may complement Ayurvedic approaches involving diet, lifestyle, and herbal formulations. In conclusion, Humanin represents a bridge between modern molecular biology and Ayurveda, offering a holistic perspective on diabetes pathophysiology. Recognizing its conceptual relationship with Prameha underscores the importance of integrative medicine in advancing personalized care. Future research should focus on validating Humanin’s biomarker potential through clinical trials and exploring synergistic therapies that combine peptide science with Ayurvedic wisdom.},
        keywords = {Diabetes Mellitus, Humanin, Mitochondria-derived peptide, Prameha},
        month = {December},
        }