COMPARISON OF THE USE OF KINETIC MODEL PLOTS BY DD SOLVER SOFTWARE TO EVALUATE THE DRUG RELEASE FROM RUTIN-MESOPOROUS SBA-15 COMPLEX
Author(s):
Sheeba FR, Dr. Allenki Venkatesham
Keywords:
Rutin, Mesoporous SBA-15, Kinetics, Models, DD solver, Dissolution profile, mathematical models
Abstract
The understanding of the release kinetics of active drugs is crucial for developing dosage forms that deliver drugs effectively and for predicting their behaviour in vivo. This study aims to investigate the mechanism of drug release from a complex of Rutin and mesoporous SBA-15 (MSBA-15) using mathematical models, and to compare the use of graphs and DD solver software in fitting dissolution profiles to kinetic models. The Rutin was loaded into MSBA-15 using the solvent evaporation technique, and a control batch of pure Rutin was also prepared for comparison. The dissolution profiles showed that the complexed formulation improved the release of Rutin compared to pure Rutin. The researchers used Excel add-in DD solver and kinetic plots to determine the kinetic model that best fits the data. The results indicate that the first-order model and the Korsmeyer-Peppas model have the highest goodness of fit parameters, with Rsqr values of 0.9742 and 0.9747, respectively. This suggests that these models are the most appropriate for describing the release kinetics of the Rutin-MSBA-15 complex from the DD solver.
Article Details
Unique Paper ID: 159515

Publication Volume & Issue: Volume 9, Issue 12

Page(s): 127 - 136
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