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@article{187207,
        author = {Miss. Ashwini C. Barde and Miss. Priyanka K. Adhav and Miss. Siddhi D. Pawar and Miss. Priyanka N. Gaikwad and Mr. Akshay R. Gadhri},
        title = {Formulation and Development of Paracetamol IP 75 mg Immediate Release Tablet Using Wet Granulation Technique},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {6},
        pages = {3617-3626},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=187207},
        abstract = {The present study focuses on the formulation and development of Paracetamol IP 75 mg immediate-release tablets using the wet granulation technique, with the objective of achieving rapid drug release, optimal mechanical strength, and batch-to-batch uniformity. Paracetamol, a widely used analgesic and antipyretic agent, requires precise dosing and consistent bioavailability, particularly in low-dose formulations intended for pediatric and geriatric use. Wet granulation was selected to overcome flowability and compressibility challenges commonly associated with fine Paracetamol powder. Various excipients—including diluents, binders, disintegrants, and lubricants—were evaluated to determine their influence on granule characteristics and final tablet performance. The process involved preparing granules using an appropriate binder solution, followed by drying, sizing, lubrication, and compression. Formulated batches were assessed for pre-compression parameters such as moisture content, angle of repose, bulk density, and compressibility index. Post-compression evaluation included weight variation, hardness, friability, disintegration time, drug content uniformity, and in-vitro dissolution studies. Among the formulations tested, the optimized batch demonstrated satisfactory granule flow properties and produced tablets with adequate hardness, low friability, and rapid disintegration within the pharmacopeial limits. The dissolution profile indicated that more than 80% of the drug was released within the first 30 minutes, confirming the immediate-release nature of the formulation. Overall, the study highlights the effectiveness of the wet granulation technique in producing a stable, uniform, and fast-acting Paracetamol IP 75 mg tablet suitable for clinical use.},
        keywords = {Paracetamol IP 75 mg; Immediate-release tablet; Wet granulation; Formulation development; Pre-compression studies; Post-compression evaluation; Dissolution profile; Disintegration; Tablet optimization.},
        month = {November},
        }