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@article{161587,
        author = {Dr. S. Naazneen},
        title = {A VALIDATED RP-HPLC METHOD FOR THE DETERMINATION OF DESIDUSTAT IN PHARMACEUTICAL DOSAGE FORM},
        journal = {International Journal of Innovative Research in Technology},
        year = {},
        volume = {10},
        number = {5},
        pages = {142-147},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=161587},
        abstract = {An accurate, sensitive, precise, fast isocratic reverse phase HPLC (RP-HPLC) method has been developed and validated for the quantification of Desidustat in bulk and pharmaceutical tablet dosage forms.  With acetonitrile as the organic solvent, the best separation was achieved on a 250 mmx 4.6 mm i.d., 5µ-particle size Inertsil®-Octadecyl-silyl-3V-Reverse-Phase-C18-column with 0.03M Potassium Dihydrogen Orthophasphate in water pH: 3.2 with Orthophosphoric acid: Acetonitrile (55:45) as the mobile phase solvent in the isocratic mode of elution at a speed of 0.8 ml.min−1. UV detection was at 246 nm. Retention time of Desidustat was 4.67 minutes. With a correlation coefficient of about 0.999, peak-response was obtained as a function of concentration over the range of 40 to 120 µg/ ml for Desidustat. Desidustat was shown to have a percentage assay of 98.6%. Desidustat had a limit of detection of 0.05 mcg/ ml and a limit of quantification (LOQ) of 0.15 mcg/ ml. The presence of excipients in the formulation had no effect on the assay method. The procedure is appropriate for use in QC- laboratories since it is economical and precise.},
        keywords = {Acetonitrile, Anemia, Desidustat, Oxemia, RP-HPLC,  Water.},
        month = {},
        }