Postmortem redistribution in forensic toxicology: challenges, mechanism, and advances in drug detection

  • Unique Paper ID: 169224
  • PageNo: 844-849
  • Abstract:
  • Postmortem toxicology is one of the most important field in forensic science as it explain the cause and manner in which a crime was committed by both qualitative and quantitative analysis of drugs, toxins, or other chemicals present in the evidence. This paper discusses the findings from recent research to show progress and hurdles in the field. Other significant issues covered are postmortem redistribution in which drug concentration may alter following death due to several physiological processes such as coagulation of blood and movement of body fluids, hence misinterpretation of toxicological samples. The review discusses the effect PMR has on the accuracy of toxicological results, and also emphasis on the importance of the drug concentrations being that are interpreted in reference to anatomical sites and the correct application of sampling methods. It describes the characteristics of drugs that are most likely affected by PMR, including protein binding, tissue decomposition, lipophilicity, how much volume of drug is distributed, the mechanism for these changes, and bacterial activity. The review later involves the improvements made in analytical technology and sample preparation, which makes the analysis of drugs in postmortem samples more efficient by using advanced chromatography and mass spectrometry methods.

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{169224,
        author = {Mahima agarwal},
        title = {Postmortem redistribution in forensic toxicology: challenges, mechanism, and advances in drug detection},
        journal = {International Journal of Innovative Research in Technology},
        year = {2024},
        volume = {11},
        number = {6},
        pages = {844-849},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=169224},
        abstract = {Postmortem toxicology is one of the most important field in forensic science as it explain the cause and manner in which a crime was committed by both qualitative and quantitative analysis of drugs, toxins, or other chemicals present in the evidence. This paper discusses the findings from recent research to show progress and hurdles in the field. Other significant issues covered are postmortem redistribution in which drug concentration may alter following death due to several physiological processes such as coagulation of blood and movement of body fluids, hence misinterpretation of toxicological samples.
The review discusses the effect PMR has on the accuracy of toxicological results, and also emphasis on the importance of the drug concentrations being that are interpreted in reference to anatomical sites and the correct application of sampling methods. 
It describes the characteristics of drugs that are most likely affected by PMR, including protein binding, tissue decomposition, lipophilicity, how much volume of drug is distributed, the mechanism for these changes, and bacterial activity.
The review later involves the improvements made in analytical technology and sample preparation, which makes the analysis of drugs in postmortem samples more efficient by using advanced chromatography and mass spectrometry methods.},
        keywords = {},
        month = {November},
        }

Cite This Article

agarwal, M. (2024). Postmortem redistribution in forensic toxicology: challenges, mechanism, and advances in drug detection. International Journal of Innovative Research in Technology (IJIRT), 11(6), 844–849.

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