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@article{171456, author = {Pragati Sharma and Raibarinder Singh and Sachin Kumar Sharma and Amisha Naik and Saurav Anand}, title = {Exploring Herbal Remedies as Therapeutic Options for Hepatotoxicity Management}, journal = {International Journal of Innovative Research in Technology}, year = {2024}, volume = {11}, number = {7}, pages = {3076-3085}, issn = {2349-6002}, url = {https://ijirt.org/article?manuscript=171456}, abstract = {The liver is the organ with the most significant metabolic activities in nature; these include the metabolism of proteins, lipids, and carbohydrates. It also has bile secretion and detoxifying properties. It is highly organized, composed of lobes and lobules mostly generated by hepatocytes, as well as non-hepatocyte cells like Kupffer cells, and accounts for around 2.5 percent of body weight. Over millions of individuals worldwide suffer from liver disease, a serious medical ailment. Fatigue, stomach pain, and jaundice are typical symptoms. Congenital abnormalities, infections, toxic substances, or drugs are the main causes of liver illnesses. Liver illnesses come in more than 100 varieties. Some of the most prevalent forms are hepatitis, cirrhosis, and non-alcoholic fatty liver disease. Hepatotoxicity refers to liver damage brought on by medications or xenobiotic exposure. Increased liver enzymes are one of the most important diagnostic indicators for this type of injury, which can be classified as intrinsic, idiosyncratic, or immunoallergic. Natural remedies for liver disorders, such as milk thistle, curcumin, ginger, licorice, and dandelion, have shown encouraging results like anti-inflammatory, anti-fibrotic, and antioxidant properties , that makes them effective. Numerous cellular pathways are modulated by these medicinal drugs.}, keywords = {Hepatotoxicity, Haemochromatosis, Aspartate aminotransferase, alanine aminotransferase, Lipid peroxidation, Inflammation, Antioxidant, Glutathione, Hydroxycinnamic acids, Chlorogenic acid, Bilirubin, Hepatic stellate cells}, month = {December}, }
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