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@article{172143,
        author = {Vaishnavi Sanjay Bhandawalkar and Gayatri Natthu Patil and Janhavi Prabhakar Patil and Mayuri kundan Patil and Sakshi Devendra Chaudhari and Dipankshi Anil Nerpagar and Gayatri Ganesh Gawande},
        title = {Cinnamic acid conjugated with Triazole acetamides was synthesized and evaluated for antialzhimer and antimelanogenesis activity},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {8},
        pages = {2328-2330},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=172143},
        abstract = {In this study, we report the synthesis of novel cinnamic acid derivatives conjugated with triazole acetamides and their subsequent evaluation for potential anti-Alzheimer and anti-melanogenesis activities. The compounds were synthesized through a series of chemical reactions, utilizing efficient coupling strategies to achieve the desired triazole-acetamide moiety attached to cinnamic acid. The structural characterization of the synthesized compounds was confirmed using NMR, mass spectrometry, and infrared spectroscopy.
Biological evaluations demonstrated that several synthesized derivatives exhibited significant inhibitory effects on key enzymes associated with Alzheimer's disease, including acetylcholinesterase, indicating potential cognitive enhancement properties. Additionally, the anti-melanogenesis activity was assessed using tyrosinase inhibition assays on melanocyte cultures, revealing that select compounds effectively reduced melanin synthesis, suggesting promising applications in the treatment of hyperpigmentation disorders.
The results highlight the potential of these cinnamic acid-triazole acetamide conjugates as dual-action therapeutics for Alzheimer's disease and skin hyperpigmentation, warranting further investigation into their mechanisms of action and in vivo efficacy. This research contributes to the development of novel pharmacological agents with multifaceted therapeutic action.},
        keywords = {Cinnamic acid, Triazole acetamides, Synthesis, Antialzhimer activity, Antimelanogenesis activity, Bioactivity, Structure activity relationship, Synthetic chemistry.},
        month = {January},
        }