Cinnamic acid conjugated with Triazole acetamides was synthesized and evaluated for antialzhimer and antimelanogenesis activity

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Vaishnavi Sanjay Bhandawalkar; Gayatri Natthu Patil; Janhavi Prabhakar Patil; Mayuri kundan Patil; Sakshi Devendra Chaudhari; Dipankshi Anil Nerpagar; Gayatri Ganesh Gawande

Cinnamic acid conjugated with Triazole acetamides was synthesized and evaluated for antialzhimer and antimelanogenesis activity

Authors: Vaishnavi Sanjay Bhandawalkar, Gayatri Natthu Patil, Janhavi Prabhakar Patil, Mayuri kundan Patil, Sakshi Devendra Chaudhari, Dipankshi Anil Nerpagar, Gayatri Ganesh Gawande

Unique Paper ID: 172143
Volume: 11
Issue: 8
PageNo: 2328-2330

Keywords: Cinnamic acid Triazole acetamides Synthesis Antialzhimer activity Antimelanogenesis activity Bioactivity Structure activity relationship Synthetic chemistry.

Abstract:
In this study, we report the synthesis of novel cinnamic acid derivatives conjugated with triazole acetamides and their subsequent evaluation for potential anti-Alzheimer and anti-melanogenesis activities. The compounds were synthesized through a series of chemical reactions, utilizing efficient coupling strategies to achieve the desired triazole-acetamide moiety attached to cinnamic acid. The structural characterization of the synthesized compounds was confirmed using NMR, mass spectrometry, and infrared spectroscopy. Biological evaluations demonstrated that several synthesized derivatives exhibited significant inhibitory effects on key enzymes associated with Alzheimer's disease, including acetylcholinesterase, indicating potential cognitive enhancement properties. Additionally, the anti-melanogenesis activity was assessed using tyrosinase inhibition assays on melanocyte cultures, revealing that select compounds effectively reduced melanin synthesis, suggesting promising applications in the treatment of hyperpigmentation disorders. The results highlight the potential of these cinnamic acid-triazole acetamide conjugates as dual-action therapeutics for Alzheimer's disease and skin hyperpigmentation, warranting further investigation into their mechanisms of action and in vivo efficacy. This research contributes to the development of novel pharmacological agents with multifaceted therapeutic action.

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ISSN: 2349-6002
Volume: 11
Issue: 8
PageNo: 2328-2330

Cinnamic acid conjugated with Triazole acetamides was synthesized and evaluated for antialzhimer and antimelanogenesis activity

Available:https://ijirt.org/article?manuscript=172143

11 Dec, 2024

Antioxidant property of herbal formulations

Impact Factor
8.01 (Year 2024)

UGC Approved
Journal no 47859

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