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@article{174503,
        author = {B Nagamani and Imandi divya and Y. RAMALAKSHMI, and B Renuka},
        title = {FORMULATION AND IN-VITRO EVALUATION OF GASTRORETENTIVE EFFERVESCENT TABLETS OF FAMOTIDINE USING ABELMOSCHUS ESCULENTUS GUM AND HPMC AS A RATE RETARDING POLYMERS},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {10},
        pages = {4274-4282},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=174503},
        abstract = {The present research work was aimed to develop the controlled release gastro retentive effervescent tablets in order to overcome the incomplete drug release from the drug delivery system above the absorption zone leading to poor bioavailability of the drug. Famotidine effervescent tablets were prepared by using abelmoschus esculentus (okra gum), HPMC K 4M, HPMC K100M in different ratios employing wet granulation method. Process and formulation parameters were optimized and the formulated effervescent tablets were evaluated for hardness, friability, weight variation test, swelling index, in-vitro buoyancy studies, content uniformity, in-vitro dissolution studies. Famotidine effervescent tablets were prepared, the optimized formulation (F3) containing (drug: abelmoschus esculentus). This shows swelling index (98.25%), content uniformity (98.78%) and effervescent tablets remained buoyant for 12hrs. The percentage of in-vitro drug release (96.36± 0.06) had better dissolution profile with desired controlled action. Abelmoschus esculentus as a natural polymer was simple and cost-effective technique.},
        keywords = {Famotidine, Abelmoschus Esculentus, Effervescent tablets, H2- receptor antagonist},
        month = {March},
        }