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@article{174566,
        author = {B Nagamani and Imandi divya and Y. RAMALAKSHMI, and B Renuka},
        title = {FORMULATION AND EVALUATION OF RITONAVIR SUSTAINED RELEASE MATRIX TABLETS},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {11},
        pages = {75-85},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=174566},
        abstract = {Ritonavir is an antiretroviral drug which belongs to the class of protease inhibitor. It has short biological half-life (3 to 5hours) and the usual oral dosage regimen is 100-400mg in divided doses. The main aim of the study is to develop sustained-release matrix tablets of Ritonavir by using different ratios of polymers. A total of thirteen formulations are designed i.e., with varying concentration of polymer in each formulation. It has been observed that the formulations prepared in combination with HPMC K4M and Ethyl cellulose, HPMC K4M and Carbopol retarded the drug release over a period of 12hours. Among all these formulations F11 (HPMC K4M & Carbopol) has shown effective sustained release (95.62 ± 2.54) over an extended period of 12 hours. Hence, F11 was considered as best formulation. Results of the present study demonstrated that both hydrophilic and hydrophobic polymers could be successfully employed for formulating sustained release matrix tablets of Ritonavir. The investigated sustained release matrix tablet was capable of maintaining constant plasma concentration up to 12 hours. This can be expected to reduce the frequency of administration and decrease the dose dependent side effects.},
        keywords = {Ritonavir, Oral dosage forms, Sustained release},
        month = {March},
        }