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@article{177319,
        author = {Dr I S Chakrapani and Dr A Indira Priyadarsini and Dr Srinivas K and Dr K Salini},
        title = {Treatment of Psoriasis - the promise of new ‘biologicals’},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {12},
        pages = {447-449},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=177319},
        abstract = {Psoriasis is a chronic, recurrent immune-mediated inflammatory dermatosis. Epidermal hyperplasia and infiltration of inflammatory cells into the dermis and neovascularization characterize this disease. The global prevalence rate is about 2-3%. It impairs the quality of life negatively, due to chronic complications and comorbidities like arthritis, cardiovascular issues, depression and metabolic disorders. The molecular mechanisms involved in psoriasis are complex, and deregulation of T-helper cells Th-1/Th-2/Th-17/Th-23 axis is implicated in the pathogenesis of the disease. Current treatment protocols for this disease have not been satisfactory. Biotechnological innovations have made possible the development of several new systemic therapies for psoriasis. ‘Biologicals’ are a new group of compounds including monoclonal antibodies, fusion proteins and recombinant proteins. Targets for the therapeutic strategies adopting the new ‘biologicals’ include inactivation of soluble mediators like tumor necrosis factor alpha, blockade of receptors for cytokines, adhesion molecules and interference with T-cell activation by antigen-presenting cells. About forty ‘biologicals’ are under examination for the management of psoriasis. Recombinant cytokines are in use to modulate immunological balance, as a therapy for psoriasis. This work reviews the recent developments in the treatment of psoriasis with new ‘biologicals’.},
        keywords = {},
        month = {May},
        }