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@article{182901,
        author = {Dr. Hema Manogna Narne and Dr. B. Thangabalan and Ms. Galaba Yamini Padmasri and Ms. Snehitha Onteru and Ms. VaraLakshmi Sanikommu and Ms. Afifa Nargees Shaik and Ms. Padmasri Sambravu and Ms. Nitya Sri Prathuri},
        title = {EXPLORING THE LINK BETWEEN SLEEP AND NEURODEGENERATIVE DISEASES},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {2},
        pages = {4008-4018},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=182901},
        abstract = {Sleep disorders are common during the clinical course of the main neurodegenerative diseases. Neurodegenerative diseases can lead to functional changes in the respiratory system that facilitate the emergence of apnea.Many neurodegenerative diseases manifest in an overall aged population, the pathology of which is hallmarked by abnormal protein aggregation. It is known that across aging, sleep quality becomes less efficient and protein homeostatic regulatory mechanisms deteriorate. Sleep disturbance such as RBD may be an early sign of neurodegeneration in these diseases, and also serve as an assessment of cognitive impairments. In an aged population, when sleep is chronically poor, and proteostatic regulatory mechanisms are less efficient, the cell is inundated with misfolded proteins and suffers a collapse in homeostasis. We also present data suggesting that reducing cellular stress and improving proteostasis and sleep quality could serve as potential therapeutic solutions for the prevention or delay in the progression of these diseases. The present study aimed to investigate the sleep disorders associated with various neurological pathologies, including amyotrophic lateral sclerosis (ALS), multiple system atrophy (MSA), hereditary ataxias, Huntington’s disease (HD), progressive supranuclear palsy (PSP), and dementia with Lewy bodies(DLB).},
        keywords = {Sleep, neurodegenerative disease, aging, sleep disturbances, ataxias, insomnia},
        month = {July},
        }