FORMULATION AND EVALUATION OF IMMEDIATE RELEASE OF CENOBAMATE

  • Unique Paper ID: 186497
  • PageNo: 2107-2126
  • Abstract:
  • The present study was aimed at the formulation and evaluation of immediate release tablets of Cenobamate, an antiepileptic drug, to achieve rapid onset of action and improved patient compliance. A total of nine formulations (F1–F9) were prepared by direct compression method using different concentrations of super disintegrants. All the prepared formulations were subjected to pre-compression and post-compression evaluation parameters, which were found to be within the acceptable limits as per the Indian Pharmacopoeia (IP) specifications. Among the formulations, F6 exhibited superior performance with rapid disintegration time, acceptable hardness, friability, and uniform drug content, along with enhanced in vitro drug release profile compared to other formulations. Thus, F6 was identified as the optimized formulation, demonstrating its potential for the development of an effective immediate release dosage form of Cenobamate.

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{186497,
        author = {VADLA TEJASWI and Dr.R.SUTHAKARAN},
        title = {FORMULATION AND EVALUATION OF IMMEDIATE RELEASE OF CENOBAMATE},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {6},
        pages = {2107-2126},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=186497},
        abstract = {The present study was aimed at the formulation and evaluation of immediate release tablets of Cenobamate, an antiepileptic drug, to achieve rapid onset of action and improved patient compliance. A total of nine formulations (F1–F9) were prepared by direct compression method using different concentrations of super disintegrants. All the prepared formulations were subjected to pre-compression and post-compression evaluation parameters, which were found to be within the acceptable limits as per the Indian Pharmacopoeia (IP) specifications. Among the formulations, F6 exhibited superior performance with rapid disintegration time, acceptable hardness, friability, and uniform drug content, along with enhanced in vitro drug release profile compared to other formulations. Thus, F6 was identified as the optimized formulation, demonstrating its potential for the development of an effective immediate release dosage form of Cenobamate.},
        keywords = {Cenobamate, Immediate Release Tablets.},
        month = {November},
        }

Cite This Article

TEJASWI, V., & Dr.R.SUTHAKARAN, (2025). FORMULATION AND EVALUATION OF IMMEDIATE RELEASE OF CENOBAMATE. International Journal of Innovative Research in Technology (IJIRT), 12(6), 2107–2126.

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