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@article{189265,
        author = {Hemant Dhakne and Sonal khandu Dhonnar and Yojana Dhuri and Diksha Dandge and Rakesh Choudhary and Sandhya Dhruve},
        title = {Quinazoline Derivatives as Multifunctional Therapeutic Agents in Drug Discovery and Development},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {5312-5340},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=189265},
        abstract = {The quinazoline ring system has emerged as a distinguished and highly adaptable scaffold in medicinal chemistry, celebrated for its planar structure, notable synthetic versatility, and ability to engage in various molecular interactions. In recent years, it has become the foundation of a diverse range of compounds that demonstrate potent pharmacological properties, including anticancer, antimicrobial, anti-inflammatory, antihypertensive, and anticonvulsant activities. Innovations in synthetic methodologies, which range from traditional anthranilic acid pathways to contemporary transition-metal-catalyzed and multicomponent reactions, have enabled the development of extensive libraries of functionalized analogues with improved efficacy and selectivity. Thorough structure-activity relationship and computational studies have played a crucial role in identifying the essential structural characteristics that influence their interaction with biological targets. The clinical success of medications such as erlotinib, gefitinib, and alfuzosin highlights the significant therapeutic potential of this heterocycle. This review aims to summarize recent progress in the synthesis, biological assessment, and mechanistic action of quinazoline derivatives, emphasizing their lasting promise as a foundational platform for next-generation therapeutics.},
        keywords = {Quinazoline, Anti-cancer, Anti-microbial, Anti-inflammatory, Anti-oxidant.},
        month = {December},
        }