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@article{189603,
        author = {Pandurang Sanjay Sawant and Priyanka Hajare},
        title = {Sustain release and Formulation strategies for nifidipine drug},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {7974-7982},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=189603},
        abstract = {Because the medication does not reach the site of action in the proper amounts, conventional drug delivery methods for treating hypertension and angina are not very effective. Strong and cautious treatment for angina and high blood pressure disorder using a certain medicine delivery method is difficult for the pharmaceutical experts. The most popular approach to drug regulation release is to incorporate it into a matrix system due to its hydrophilic and pliable nature. In oral controlled medication administration, polymer matrices are frequently utilized to achieve a systematic, wide-ranging regulatory compliance, and a desired medication release pattern. Nifedipine sustained release matrix tablet formulation was created by The polymers combine to produce the desired profile of medication release. Evaluation The prepared pills' hardness, friability, thickness, and medicationcontent homogeneity, weight fluctuation, and the pattern of in vitro drug release. 97% of the drug was released at 24 hours in the formulation made with HPMC K100M, while 99% of the drug was released at 20 hours in the formulation made with Eudragit.The current study's goal was to create and assess a sustained release matrix tablet of nifedipine using natural polymers. The tablets were made using direct compression technique utilizing various Guar dosages gum and Xanthan gum as organic polymers. The ready Tablets were assessed for pre-compression characteristics such bulk density, angle of repose, tapped density, Hausner's ratio, compressibility index, and post-compression factors like thickness, hardness, and weight fluctuation, friability, consistency of substance, swelling index, and in vitrostudies on disintegration. FTIR analysis revealed that there was no drug-polymer interaction. The best possible sustained Drug release over a 12-hour period was demonstrated by formulation F9. The improved formulation's "n" value showed that the medication release adheres to the unusual non-Fickian Release The stability investigations verified that the optimized formulation held steady at 40 °C and 75% relative humidity.},
        keywords = {Nifedipine, Control release, GITS, Matrix Tablets, Pharmacokinetics, Zero-order Release, Hypertension.},
        month = {December},
        }