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@article{190745,
        author = {Dr. Harshal Sampatrao Sabale},
        title = {A COMPREHENSIVE REVIEW OF THE CONCEPT OF UPADHATU IN AYURVEDIC SAMHITAS},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {4},
        pages = {4663-4666},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=190745},
        abstract = {The concept of Upadhatu represents a vital physiological framework within Ayurveda, essential for understanding tissue metabolism and secondary structural development. While the Sapta Dhatu (seven primary tissues) form the foundational pillars of the human body, Upadhatus serve as specialized derivatives that perform specific physiological functions without undergoing further transformation into subsequent tissues. This distinction is critical in Ayurvedic biology, as Upadhatus do not possess the "Dharana" and "Poshanam" (nourishing) capabilities required to generate the next tissue in the metabolic chain. This review systematically examines the definition, origin, and clinical significance of Upadhatus as documented in the classical Ayurvedic Samhitas, including the Charaka Samhita, Sushruta Samhita, and Ashtanga Hridaya. According to Ayurvedic physiology, Upadhatus are formed from the nutrient portion (Prasada bhaga) of the primary Dhatus during the process of metabolic transformation mediated by Dhatvagni (tissue-specific fire). For instance, Stanya (breast milk) and Artava (menstrual fluid) are derived from Rasa Dhatu, while Kandara (tendons) and Jala (fascia) originate from Mamsa Dhatu. Understanding Upadhatus is clinically indispensable for diagnosing various pathological states. Since they are nourished by the primary Dhatus, any qualitative or quantitative depletion in the Dhatu directly manifests as a dysfunction in its corresponding Upadhatu. This review highlights their role in structural integrity, reproductive health, and locomotor functions. By synthesizing classical perspectives with contemporary physiological relevance, this study underscores the importance of Upadhatus in holistic assessment and the management of chronic degenerative conditions, providing a comprehensive lens through which secondary tissue dynamics can be evaluated.},
        keywords = {Ayurveda, Upadhatu, Sapta Dhatu, Dhatvagni, Metabolism, Kandara, Stanya Physiological Derivatives},
        month = {January},
        }