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@article{191599,
        author = {Sachin Gholve and KeshavraoBapurao Kulkarni},
        title = {Transdermal Patches for Diabetic Wound Healing using Moringa oleifera},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {7109-7121},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=191599},
        abstract = {Diabetic wounds are among the most serious and common complications associated with diabetes mellitus. These wounds are characterized by delayed and impaired healing due to prolonged inflammation, excessive oxidative stress, reduced collagen synthesis, compromised angiogenesis and a higher susceptibility to microbial infections. Such pathological conditions often lead to chronic, non-healing ulcers, significantly affecting patient quality of life and increasing the risk of infection, hospitalization, and limb amputation.
In recent years, herbal therapies have gained considerable attention in wound management owing to their safety, biocompatibility, and multifunctional therapeutic effects. Among various medicinal plants, Moringa oleifera has been extensively studied for its rich phytochemical composition. The plant is a valuable source of flavonoids, polyphenols, vitamins, and essential amino acids, which collectively contribute to its strong antioxidant, anti-inflammatory, antimicrobial, and wound-healing properties. These bioactive constituents play a crucial role in reducing oxidative damage, controlling inflammation, preventing infection, and promoting tissue regeneration.
The present study was designed to develop and evaluate transdermal patches containing Moringa oleifera extract as a novel approach for diabetic wound healing. Transdermal patches were formulated using suitable polymeric materials by the solvent casting method to ensure uniformity, flexibility, and controlled drug delivery. The prepared patches were systematically evaluated for physicochemical characteristics, drug content uniformity, in vitro drug release behavior, and wound healing potential.
The optimized transdermal patch exhibited satisfactory mechanical strength, uniform distribution of the herbal extract, and a sustained drug release profile, which is essential for maintaining continuous therapeutic levels at the wound site. Enhanced wound healing activity observed with the optimized formulation can be attributed to prolonged drug residence time, improved skin permeation, and the synergistic biological effects of Moringa oleifera phytoconstituents.
In conclusion, transdermal patches loaded with Moringa oleifera extract offer a promising, non-invasive, and patient-friendly strategy for the effective management of diabetic wounds. This delivery system not only improves therapeutic efficacy but also has the potential to enhance patient compliance and overall wound healing outcomes.},
        keywords = {},
        month = {January},
        }