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@article{179207, author = {Jayshri A. Kavthekar and Vedant Kaminwar and Shubhangi Khating and Anjali Kamble and Sanika Kadam}, title = {mRNA Vaccine Technology: A Review of the Current State and Future Prospects}, journal = {International Journal of Innovative Research in Technology}, year = {2025}, volume = {11}, number = {12}, pages = {6832-6841}, issn = {2349-6002}, url = {https://ijirt.org/article?manuscript=179207}, abstract = {The high potency, safety, and efficacy of mRNA vaccines, along with their potential for quick and inexpensive production, have made them a potent substitute for conventional vaccines. These vaccines have advanced from being just interesting to becoming the leading COVID-19 pandemic vaccines. Significant progress has been made in the field of nanotechnology for creating mRNA vaccine delivery systems. To improve the stability of the mRNA vaccine, scientists have altered the mRNA structure. In this review, we have summarized each and every aspect of mRNA vaccine. The article describe the mRNA structure, discussing its modifications and the subsequent manufacturing processes. This includes the upstream, downstream, and formulation processes, which are essential for the production of mRNA vaccines. Furthermore, the article provides an in-depth analysis of the mechanism through which mRNA vaccines function, storage condition for mRNA vaccine and its applications. mRNA vaccines can be used for much more than just preventing infectious diseases. They are being researched for use in cancer treatment, regenerative medicine, immunotherapy, and genetic disorders. In particular, mRNA vaccines have the potential to utilize immunotherapies, treat cancer, and manage infectious diseases.}, keywords = {mRNA Vaccine, Infectious diseases (COVID-19), Lipid based nanoparticles, Immunotherapy, Cancer}, month = {May}, }
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