A Review -Development and Validation of Stability-Indicating RP-HPLC Methods for Simultaneous Estimation of Amlodipine and Telmisartan

  • Unique Paper ID: 191719
  • PageNo: 7878-7881
  • Abstract:
  • Long-acting calcium channel blockers like amlodipine and Telmisartan are frequently used in conjunction with other antihypertensive medications to treat hypertension and angina pectoris. Its stability evaluation and quality control depend on precise and trustworthy analytical techniques. The active pharmaceutical ingredient (API) must be separated from its breakdown products created under stress settings using stability-indicating techniques. Because of its excellent sensitivity, selectivity, and repeatability, reverse phase high performance liquid chromatography (RP-HPLC) has become the most popular method. The development and validation of stability-indicating RP-HPLC techniques for the simultaneous measurement of amlodipine in pharmaceutical dosage forms are the main topics of this review. A critical discussion is held on method development methodologies, forced degradation studies, validation parameters in accordance with ICH guidelines, and stated analytical conditions.

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{191719,
        author = {Ms.Shamal Rohidas Doke and Prof.Seema Bansode},
        title = {A Review -Development and Validation of Stability-Indicating RP-HPLC Methods for Simultaneous Estimation of Amlodipine and Telmisartan},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {7878-7881},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=191719},
        abstract = {Long-acting calcium channel blockers like amlodipine and Telmisartan are frequently used in conjunction with other antihypertensive medications to treat hypertension and angina pectoris. Its stability evaluation and quality control depend on precise and trustworthy analytical techniques. The active pharmaceutical ingredient (API) must be separated from its breakdown products created under stress settings using stability-indicating techniques. Because of its excellent sensitivity, selectivity, and repeatability, reverse phase high performance liquid chromatography (RP-HPLC) has become the most popular method. The development and validation of stability-indicating RP-HPLC techniques for the simultaneous measurement of amlodipine in pharmaceutical dosage forms are the main topics of this review. A critical discussion is held on method development methodologies, forced degradation studies, validation parameters in accordance with ICH guidelines, and stated analytical conditions.},
        keywords = {Amlodipine, Telmisartan, RP-HPLC, Stability-indicating method, Simultaneous estimation, Method validation},
        month = {January},
        }

Cite This Article

Doke, M. R., & Bansode, P. (2026). A Review -Development and Validation of Stability-Indicating RP-HPLC Methods for Simultaneous Estimation of Amlodipine and Telmisartan. International Journal of Innovative Research in Technology (IJIRT), 12(8), 7878–7881.

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