Creation and Assessment of an Aspirin-Loaded Nano-emulsion for Improved Topical Administration

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Dr.Ravi Hole; Mr.Naeem Maner; Ms.Monika Khatmode; Mr. Shryash Bandgar

Creation and Assessment of an Aspirin-Loaded Nano-emulsion for Improved Topical Administration

Authors: Dr.Ravi Hole, Mr.Naeem Maner, Ms.Monika Khatmode, Mr. Shryash Bandgar

Unique Paper ID: 182729
Volume: 12
Issue: 2
PageNo: 3019-3027

Keywords: Anti-inflammatory Stability Viscosity Nanoemulsion Zeta potential

Abstract:
The present study investigated the anti-inflammatory and analgesic activities of novel aspirin oil- inwater (o/w) nanoemulsion and water in oil in water (w/o/w) nano multiple emulsion formulations generated using ultrasound cavitation techniques. The objective of this work was to increase the bioavailability of aspirin. Aspirin is a non-steroidal anti-inflammatory drug. Aspirin is classified in the non-selective Cox inhibitors. The results show that oral administration of Nanoemulsion and nano multiple emulsion containing aspirin(60mg/mg) significantly reduced pain. The aspirin is used to relieve mild to moderate pain arthritis and inflammation and aspirin also prevent the blood clots and reduce the risk of heart attacks and strokes. Both nano formulations number of abdominal constriction in acetic acid induce writing model. One of the most efficient disperse nanosystems is nano emulsion having droplet size ranging to sub Micron size nano emulsions are thermodynamically stable,clear,isotropic liquid mixtures of oil,water surfactant and Co surfactant. The droplet size of nanoemulsions falls typically in the range 20-200 nanometer.The stability of nanoemulsion formulations can be maintained by a surfactant and co-surfactant. These experimental studies suggest that nano emulsion and nano multiple emulsion produce a pronounced anti-inflammatory & analgesic effects in rats and may be candidates as new nanocarriers for pharmacological NSAIDS in the treatment of inflammatory disorders and alleviating pains. The present study is important for the evaluation of anti-inflammatory and analgesic properties of both the Nanoemulsion and nanomultiple emulsion generated using ultra sound cavitation technique.

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Cite This Article

ISSN: 2349-6002
Volume: 12
Issue: 2
PageNo: 3019-3027

Creation and Assessment of an Aspirin-Loaded Nano-emulsion for Improved Topical Administration

Available:https://ijirt.org/article?manuscript=182729

Impact Factor
8.01 (Year 2024)

UGC Approved
Journal no 47859

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