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@article{205245,
        author = {Dr. Swati Rathore and Amit Sahu},
        title = {EMERGING TRENDS IN ANTIDIABETIC MEDICATIONS: A REVIEW OF CURRENT EVIDENCE},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {7808-7816},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=205245},
        abstract = {Type 2 diabetes mellitus (T2DM) is a major global health issue caused by multi-organ metabolic imbalances. Over the past decade, diabetes management has shifted from simply lowering blood sugar (a glucocentric model) to actively protecting vital organs, such as the heart and kidneys. This comprehensive review examines new and emerging antidiabetic treatments, their underlying biological mechanisms, and their clinical effects. We evaluate sodium-glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 RAs), which are now prioritized for their ability to prevent heart failure and slow chronic kidney disease. We also discuss updates on dipeptidyl peptidase-4 (DPP-4) inhibitors and next-generation, once-weekly basal insulins like insulin icodec and insulin efsitora alfa. Additionally, we look at new combination therapies and modern treatment guidelines before exploring investigational targets currently in clinical development. These include glycogen synthase kinase-3 (GSK-3) inhibitors, glucagon receptor antagonists (GCRAs), and fibroblast growth factor 21 (FGF21) analogues. Finally, the role of precision medicine-guided by genetics and metabolic markers-is balanced against current practical challenges like medication cost, patient access, and long-term safety.},
        keywords = {Type 2 Diabetes Mellitus, SGLT2 Inhibitors, GLP-1 Receptor Agonists, Chronic Kidney Disease, Insulin Icodec, Glycogen Synthase Kinase-3.},
        month = {June},
        }