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@article{205788,
        author = {Manyam Charishma and G Srinivasa Rao and R Gowtham Chakra and Guduru Rajeswari},
        title = {PRECLINICAL ASSESSMENT OF THE WOUND HEALING ACTIVITY OF ASPIDOSPERMA TOMENTOSUM WHOLE PLANT EXTRACT THROUGH EXCISION AND INCISION WOUND MODELS},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {7607-7610},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=205788},
        abstract = {Wound healing is a complex biological process involving inflammation, proliferation, angiogenesis, collagen synthesis, extracellular matrix remodeling, and tissue regeneration. Delayed wound healing remains a significant clinical challenge, particularly in patients suffering from infections, diabetes mellitus, malnutrition, and vascular disorders. Traditional medicinal plants have gained considerable attention as potential alternatives to synthetic wound healing agents due to their safety, affordability, and multiple pharmacological activities. The present study was undertaken to evaluate the wound healing potential of hydroalcoholic extract of Aspidosperma tomentosum using excision, incision, and dead-space wound models in experimental rats. Preliminary phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, phenolic compounds, saponins, and glycosides. The wound healing activity was assessed through measurement of wound contraction, tensile strength, granulation tissue formation, hydroxyproline content, protein content, DNA content, and antioxidant parameters. Treatment with the extract significantly accelerated wound contraction, enhanced collagen synthesis, increased tensile strength, and improved antioxidant enzyme levels when compared with control animals. Histopathological observations further confirmed improved tissue regeneration and epithelialization. The findings indicate that Aspidosperma tomentosum possesses significant wound healing activity, which may be attributed to its antioxidant and collagen-promoting properties.},
        keywords = {Aspidosperma tomentosum, Wound Healing, Excision Wound, Incision Wound, Hydroxyproline, Antioxidant Activity.},
        month = {June},
        }