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@article{205786,
        author = {Mocharla Bhavyasai and G Srinivasa Rao and V Lakshmi Narayana and Guduru Rajeswari},
        title = {PROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF Aspidosperma Tomentosum AGAINST SCIATIC NERVE LIGATION-INDUCED NEUROPATHIC PAIN IN RATS},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {7635-7638},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=205786},
        abstract = {Neuropathic pain is a chronic neurological disorder resulting from injury or dysfunction of the somatosensory nervous system and is characterized by spontaneous pain, hyperalgesia, allodynia, and sensory disturbances. Current pharmacological therapies provide only symptomatic relief and are frequently associated with adverse effects. Therefore, the search for novel plant-based therapeutics with improved efficacy and safety profiles has become increasingly important. The present study was undertaken to investigate the protective effect of the ethanolic extract of Aspidosperma tomentosum against sciatic nerve ligation-induced neuropathic pain in rats. Preliminary phytochemical screening of the extract revealed the presence of alkaloids, flavonoids, tannins, phenolic compounds, carbohydrates, and glycosides. Adult Wistar rats were divided into four groups comprising control, disease control, and treatment groups receiving EEAT at 200 mg/kg and 400 mg/kg. Neuropathic pain was induced through partial sciatic nerve ligation. Behavioral assessments including foot deformity score, tail withdrawal latency, locomotor activity, motor coordination, and transfer latency were performed. Biochemical parameters such as superoxide dismutase, reduced glutathione, and malondialdehyde were estimated to evaluate oxidative stress. Treatment with EEAT significantly improved behavioral abnormalities and restored antioxidant enzyme levels compared with disease control animals. The higher dose exhibited greater neuroprotective activity. The results suggest that Aspidosperma tomentosum possesses significant antineuropathic activity, possibly mediated through antioxidant and neuroprotective mechanisms.},
        keywords = {Aspidosperma tomentosum, Neuropathic Pain, Sciatic Nerve Ligation, Oxidative Stress, Neuroprotection, Antioxidant Activity.},
        month = {June},
        }