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@article{206540,
        author = {Dr. S. Lokeshwaran and Dr.G.Andhuvan and Dr. R.P. Ramkumar},
        title = {STUDY ON OCCURRENCE OF ADVERSE DRUG REACTION IN INTENSIVE CARE UNIT},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {2},
        pages = {1889-1893},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=206540},
        abstract = {Adverse Drug Reactions (ADRs) are undesirable effects of medications used in normal doses. The study observed a higher incidence of adverse drug reactions (ADRs) in ICU compared to other hospital areas, likely due to differences in surveillance systems and the higher risk profile of ICU patients with comorbidities and multiple drug therapy. Inclusion criteria targeted patients of any age and sex who developed an ADR during ICU admission, while excluding cases of drug abuse, overdose, unwilling participants, and those with insufficient data. Demographic and clinical data were collected, and Naranjo’s Causality Assessment Scale assessed ADR risk. Out of 174 patients studied, 61.49% were men, with the majority (40.95%) being in late adulthood. Gastrointestinal issues were the most prevalent (33.33%), often linked to antibiotics (28.16%). Naranjo’s scale classified most ADRs as probable (67.24%), and severity assessment (Hartwig’s scale) indicated 53.44% were mild. Preventability analysis (Modified Schumock and Thornton scale) suggested 68.39% were likely preventable. Recovery occurred in 79.73% of cases, with ADR reduction in 20.38% and one fatality (0.57%) reported. Drug dechallenge occurred in 94.82% and rechallenge in 5.17% of cases. The study underscores a male predominance and the prevalence of late adulthood patients. Antibiotics were a significant contributor to ADRs, emphasizing the need for cautious antibiotic prescribing. Gastrointestinal issues were the most affected organ system. Most ADRs were probable, mild, and likely preventable. Identified risk factors included age, comorbidities, and polypharmacy. Standardized procedures implementation is advocated to mitigate ADR occurrences and ensure ICU patient safety.},
        keywords = {Adverse drug reaction, Intensive Care Unit, ADR Causality, Severity and preventability Assessment},
        month = {July},
        }