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@article{207234,
        author = {MISS MAYURI S.PATIL and Miss Swati G. Patil and Miss. Aachal V Patil},
        title = {FORMULATION AND EVALUATION OF IRBESARTAN NANOEMULSION.},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {3},
        pages = {480-490},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=207234},
        abstract = {Irbesartan, a Biopharmaceutics Classification System (BCS) class II antihypertensive drug, suffers from poor aqueous solubility and a high dosing frequency that limit patient compliance.
Method: In the present study, an Irbesartan-loaded oil-in-water nanoemulsion was developed by the ultrasound emulsification method to improve drug solubilization and reduce dosing frequency. A total of two nanoemulsion batches were formulated and compared: Batch MY1, stabilized using the synthetic polymeric surfactant Pemulen-Tr1, and Batch MY2, stabilized using the natural surfactant gum acacia. Batch MY1 was optimized using a 3² full factorial design comprising eight formulations (MY1-1 to MY1-8), with the amount of oil (Capryol 90), amount of Pemulen-Tr1, and sonication time as independent variables, and particle size, polydispersity index (PDI), and zeta potential as response variables. 
Result :Among the eight batches, formulation MY1-8, containing 1 mL of Capryol 90 as the oil phase and 15 mg of Pemulen-Tr1 as the polymeric surfactant, sonicated for 6 minutes, was identified as the optimized formulation, showing the smallest particle size (264.6 nm), lowest PDI (0.225), and a zeta potential of -40.2 mV, indicative of good physical stability. 
Conclusion:These findings indicate that Pemulen-Tr1, at a concentration of 15 mg per batch, is an effective polymeric stabilizer for producing a stable, sub-300 nm Irbesartan nanoemulsion with improved dissolution characteristics.},
        keywords = {Irbesartan; Nanoemulsion; Pemulen-Tr1; Factorial design; Bioavailability},
        month = {August},
        }