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@article{208830,
        author = {Dr Mital Bhatt and Dr Samir Kanani and Dr Amar Sheth},
        title = {CLINICAL EFFECTIVENESS OF INDIVIDUALISED HOMOEOPATHIC TREATMENT IN PRIMARY HYPOTHYROIDISM: A PROSPECTIVE, INTERVENTIONAL CLINICAL STUDY},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {4},
        pages = {2798-2804},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=208830},
        abstract = {Background: Primary hypothyroidism is a common endocrine disorder, characterised by thyroid hormone deficiency and metabolic slowing. Conventional levothyroxine sodium supplementation is effective in stabilising serum thyroid-stimulating hormone (TSH) in 80–90% of patients. This clinical study evaluated the efficacy of individualised homoeopathic treatment in primary hypothyroidism.
Objective: To evaluate the clinical and biochemical effectiveness of individualised homoeopathic medicines in primary hypothyroidism and to identify the most frequently indicated constitutional remedies, miasmatic representations, and potency patterns.
Methodology: A prospective, interventional, single-arm clinical trial of 30 consenting adults with primary hypothyroidism was conducted over a 9-month follow-up period. Complete case-taking and repertorisation (using Synergy Materia Medica Software) were performed to select a single constitutional remedy starting at 30C potency. Serum TSH, T3, and T4 levels were measured every 3 months. We graded tissue-level hypothyroid status using the Zulewski Clinical Score (seven symptoms, five signs) before and after treatment. A paired t-test was used for statistical analysis.
Results: Out of 30 patients, 22 (73.3%) showed marked clinical and biochemical improvement. Mean serum TSH levels decreased from 11.11 ± 6.02 mIU/L to 6.82 ± 5.93 mIU/L (p < 0.0001, highly significant). The mean Zulewski Clinical Score significantly decreased from 5.53 ± 1.17 to 2.27 ± 1.66 (p < 0.0001). Calcarea carbonica (13.33%), Bryonia, Ferrum Met, Natrum Mur, and Pulsatilla (10.0% each) were the most frequently indicated constitutional remedies. Chronic sycotic miasm (60%) predominated. Non-response was limited to four cases (13.3%), notably both cases of syphilis miasm.
Conclusion: Individualised homoeopathic treatment is highly effective in restoring biochemical thyroid balance, providing complete clinical relief, and improving general well-being. It represents a safe, holistic, and affordable alternative or adjunctive therapeutic approach to lifelong hormone replacement therapy.},
        keywords = {Primary Hypothyroidism, Individualised Homoeopathy, Constitutional Similimum, Zulewski Clinical Score, Thyroid-Stimulating Hormone (TSH), Miasms, Sycosis.},
        month = {September},
        }