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@article{209026,
        author = {Dr. Laxprad and Dr. Ranu Nandurkar and Dr. Sarvashree Nandurkar},
        title = {Clinical Evolution of Pemphigus Vulgaris Under Individualized Homoeopathic Management: A Case Report.},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {5},
        pages = {169-174},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=209026},
        abstract = {Background: Pemphigus vulgaris (PV) is an autoimmune intraepidermal blistering disorder characterized by acantholysis resulting from autoantibodies directed predominantly against desmosomal proteins, particularly desmoglein-3 and, in mucocutaneous disease, desmoglein-1. Although the trunk, scalp and mucous membranes are commonly affected, lesions may also involve the hands and other peripheral sites. Accurate diagnosis requires correlation of clinical findings with histopathology and immunopathological investigations.
Case Presentation: A 32-year-old male presented with recurrent blistering eruptions predominantly over both hands for approximately five months. The lesions initially appeared as small, fragile blisters and subsequently ruptured, producing painful superficial erosions and crusting. The patient complained of burning and tenderness at the affected sites, with aggravation following friction and manual activity. Oral mucosal discomfort was also reported intermittently. Clinical examination revealed multiple superficial erosions and crusted lesions over the dorsal and palmar aspects of both hands, with a positive Nikolsky sign. Histopathology demonstrated suprabasal intraepidermal separation with acantholytic cells. Direct immunofluorescence showed intercellular IgG and C3 deposition in a characteristic reticular pattern, supporting the diagnosis of pemphigus vulgaris. Following individualized homoeopathic case analysis, Mercurius solubilis was prescribed.
Outcome: During subsequent follow-up, a progressive reduction in the frequency of new eruptions and healing of existing erosions was documented. Burning and tenderness also decreased, with improvement in functional use of the hands. The clinical course was assessed longitudinally.
Conclusion: This case describes the longitudinal management of diagnostically established pemphigus vulgaris with predominant hand involvement using individualized homoeopathic treatment. The observed improvement cannot establish therapeutic causation from a single case and should be considered hypothesis-generating.},
        keywords = {Pemphigus vulgaris; hand lesions; autoimmune blistering disease; acantholysis; homoeopathy; case report.},
        month = {October},
        }