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@article{209087,
        author = {Asha Nandabaram and Kalvala Poojitha and Manisha R.L and Bhavani Bachu and Muvvala Sudhakar},
        title = {Nephroprotective Effect of Hydroalcoholic Leaf Extract of Tagetes erecta L. Against Gentamicin-Induced Nephrotoxicity in Wistar Rats},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {5},
        pages = {693-703},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=209087},
        abstract = {Gentamicin is a widely used aminoglycoside antibiotic whose clinical value is limited by proximal tubular toxicity. This study evaluated the nephroprotective effect of the hydroalcoholic (ethanol:water, 70:30 v/v) leaf extract of Tagetes erecta L. (TE) against gentamicin-induced nephrotoxicity in Wistar rats. Leaves were defatted with petroleum ether, extracted by the Soxhlet method and screened for phytoconstituents. Thirty rats were divided into five groups (n = 6): normal control; toxicant control (gentamicin 10 mg/kg/day intraperitoneally (i.p.) for 5 days); standard (silymarin 100 mg/kg orally (p.o.) + gentamicin); and TE 50 or 100 mg/kg p.o. + gentamicin. Serum alkaline phosphatase (ALP), blood urea nitrogen (BUN), creatinine, albumin and uric acid were estimated, and kidneys were examined histologically. The extract contained flavonoids, tannins, saponins, glycosides, alkaloids and triterpenoids. Gentamicin significantly increased ALP (286.58 ± 0.33 U/L), BUN (41.48 ± 0.64 mg/dL) and uric acid (12.54 ± 0.36 mg/dL) and decreased albumin (2.80 ± 0.04 g/dL) compared with normal rats (p < 0.001), whereas the rise in creatinine was not significant. TE 100 mg/kg significantly lowered ALP (211.92 ± 3.84 U/L) and uric acid (8.29 ± 0.15 mg/dL) and restored albumin (4.45 ± 0.18 g/dL) (p < 0.001). Both doses reduced BUN, with a greater reduction at 50 mg/kg. Tubular necrosis, casts and inflammatory infiltration seen after gentamicin were attenuated by the extract, most clearly at 100 mg/kg. T. erecta leaf extract, therefore, offers partial protection against gentamicin-induced renal injury.},
        keywords = {Gentamicin, Hydroalcoholic extract, Nephroprotective activity, Silymarin, Tagetes erecta, Wistar rats.},
        month = {October},
        }