A Review on Colon Targeted Drug Delivery System
Vikram Patil, Pratik Gavate, Renuka R. Deshpande, Nandkishor B. Bavage, Vidyasagar Gali, Shyamlila B. Bavage
Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amoebiosis, colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs. To achieve successful colon targeted drug delivery, a drug need to be protected from degradation, release and absorption in upper portion of the GI tract and then to be ensured abrupt or controlled release in the proximal colon. This review is focused on the merits and demerits, novel approaches in the colon targeted drug delivery, clinical evaluation techniques and some information on the marketed dosage forms.
Article Details
Unique Paper ID: 149516

Publication Volume & Issue: Volume 6, Issue 12

Page(s): 658 - 662
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