AZELAIC ACID IN THE TREATMENT OF ACNE VULGARIS
Author(s):
Manasi Patilghote, Dhanraj N. Wasmate, Shyamlila B. Bavage, Nandkishor B. Bavage
Keywords:
Antimicrobial, Acne vulgaris, Azelaic acid, Topical.
Abstract
Acne vulgaris is a common chronic skin disease involving blockages and inflammation when hair follicles plug with oil and dead skin cells. It may result in the formation of blackheads, whiteheads, pinheads, large papules, pimples and scarring. Azelaic acid is a naturally occurring saturated mineral carbon dicarboxylic acid. Azelaic acid is used to treat acne for the following reasons: it possesses a middle range of antityrosinase activity, is inexpensive and more soluble to be incorporated into a base cream that other dicarboxylic acids. Azelaic acid has antimicrobial activity may attribute to inhibition of microbial cellular protein synthesis and direct anti inflammatory properties due to its scavengers activity of free oxygen radical which make it effective in treatment of acne vulgaris. It is effective against a number of skin conditions such as mild to moderate acne, when applied topically in a cream formulation of 20%. It works in part by stopping the growth of skin bacteria that cause acne. Preliminary clinical studies proved effectiveness of topical azelaic acid can be considered an effective therapy chiefly for papulo pustular acne.
Article Details
Unique Paper ID: 152361

Publication Volume & Issue: Volume 8, Issue 3

Page(s): 7 - 11
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