SYNTHESIS, ANTHELMINTIC AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL (4- (2 - ((SUBSTITUEDi) METHYL))) -1H-BENZOi[D] IMIDAZOL-1-YL) PYRIDIN-2-YL) (1H-IMIDAZOL-1-YL) METHANONES
Author(s):
Srikanth Lingala, Dr Pasham Venkanna
Keywords:
Benzimidazoles, Anthelmintic activity, Albendazole, Amikacin
Abstract
Anthelmintic drugs resistance has created a major problem over the world. As per World Health Organization only few drugs are used for the therapy of helminth infections in the human population. Taking this into consideration we have made attempts to synthesize and evaluate some novel benzimidazole molecules having side chain of (4-chloropyridin-2-yl) (1H-imidazol-1-yl) methanone at the 1H position of the benzimidazoles. Few novel 4- (2 - ((substituted) methyl) -1H-benzo [d] imidazol-1-yl) -N-methylpyridine-2-carboxamide (Va-Vq) have been synthesized as given in the scheme. All the intermediate compounds and the final molecules were purified and the chemical structures are confirmed by IR, 1H NMR and Mass spectral data. All the newly synthesized molecules have been tested for their anthelmintic activity on adult Indian earthworms (pheretima posthuma) at various concentrations (0.2% and 0.5%) and antibacterial activity on B. subtilis, B. cereus, S. epidermidis, S. typhi, P. aeruginosa and K. pneumonia. All the newly synthesized molecules showed good activities when compared to the standard molecules.
Article Details
Unique Paper ID: 152700

Publication Volume & Issue: Volume 8, Issue 4

Page(s): 60 - 65
Article Preview & Download


Share This Article

Conference Alert

NCSST-2021

AICTE Sponsored National Conference on Smart Systems and Technologies

Last Date: 25th November 2021

SWEC- Management

LATEST INNOVATION’S AND FUTURE TRENDS IN MANAGEMENT

Last Date: 7th November 2021

Go To Issue



Call For Paper

Volume 8 Issue 4

Last Date 25 September 2021

About Us

IJIRT.org enables door in research by providing high quality research articles in open access market.

Send us any query related to your research on editor@ijirt.org

Social Media

Google Verified Reviews

Contact Details

Telephone:6351679790
Email: editor@ijirt.org
Website: ijirt.org

Policies