Nanomedicine based approaches for m-RNA delivery

Ms. Shilpa Amit Shinde; Dr. Madhu B. Krishnegowda; Pallavi Ganesh Borse; Omkar Santosh Sonawane; Mayuri Macchindra Landave

Nanomedicine based approaches for m-RNA delivery

Authors: Ms. Shilpa Amit Shinde, Dr. Madhu B. Krishnegowda, Pallavi Ganesh Borse, Omkar Santosh Sonawane, Mayuri Macchindra Landave

Unique Paper ID: 167564
Volume: 11
Issue: 3
PageNo: 1400-1405

Keywords: mRNA delivery; mRNA engineering; Nanomedicine; mRNA therapeutics; Clinical translation

Abstract:
Messenger RNA (mRNA) holds remarkable promise for a broad spectrum of therapeutic applications, including immunotherapy and protein replacement. Unlike traditional genetic therapies, mRNA does not integrate into the host genome or require nuclear entry for transfection, enabling protein production even in nondividing cells. This characteristic underscores mRNA-based therapies as potentially safe and versatile treatment options. However, challenges such as the large size of mRNA, its inherent immunogenicity, limited cellular uptake, and susceptibility to enzymatic degradation pose significant barriers to its therapeutic use. Advances in mRNA modifications have improved its stability and reduced immunogenicity, but optimizing mRNA delivery remains crucial for enhancing therapeutic efficacy. Nanomedicine has emerged as a transformative approach to address these challenges, offering precise control over the delivery, protection, and release of mRNA within biological systems. This review explores recent advancements in nanomedicine-based strategies for mRNA delivery, highlighting various nanocarriers, targeting techniques, and their applications in clinical settings. We also discuss ongoing challenges and future directions for improving mRNA delivery systems to facilitate their successful translation into effective therapies.

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Cite This Article

ISSN: 2349-6002
Volume: 11
Issue: 3
PageNo: 1400-1405

Nanomedicine based approaches for m-RNA delivery

Available:https://ijirt.org/Article?manuscript=167564

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