Copyright © 2025 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{167718,
        author = {Ms.Ruchi Rohit Bhuran and Ms. Desale Roshani and Mr. Akshay Uttareshwar Landge and Ms.Poonam kasar and Mr. Rahul Shivaji Adnaik and Ms.Divya Vishwas Patil},
        title = {Advancements in Drug Discovery: The Role of Combinatorial Chemistry and High-Throughput Screening},
        journal = {International Journal of Innovative Research in Technology},
        year = {2024},
        volume = {11},
        number = {4},
        pages = {148-157},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=167718},
        abstract = {Combinatorial chemistry and high-throughput screening (HTS) are transformative techniques in drug discovery, enabling the rapid synthesis and evaluation of large libraries of chemical compounds. Combinatorial chemistry allows for the generation of diverse chemical libraries by systematically combining sets of building blocks to create a vast array of potential drug candidates. This method significantly accelerates the drug discovery process by producing numerous analogues of a lead compound for biological evaluation. High-throughput screening complements combinatorial chemistry by automating the testing of these large compound libraries against biological targets, such as proteins or enzymes. HTS utilizes advanced robotic systems, miniaturized assays, and sensitive detection methods to evaluate thousands to millions of compounds in a relatively short period. This approach identifies active compounds, or "hits," that exhibit desired biological activity, which can then be optimized through further chemical modifications. Together, combinatorial chemistry and high-throughput screening have revolutionized the early stages of drug development, increasing the efficiency of identifying novel therapeutic agents. These techniques reduce the time and cost associated with traditional drug discovery methods, allowing for the rapid identification of promising drug candidates and facilitating the development of new treatments for various diseases.},
        keywords = {Combinatorial Chemistry, Combinatorial Library, Drug Discovery, High-Throughput Screening, Computer-Assisted Drug Design, One-Bead One-Compound Library, DNA-Encoded Chemical Library},
        month = {September},
        }