Formulation and Evaluation of Fast-Dissolving Tablets Incorporating Salbutamol Sulphate and Cetirizine Hydrochloride: An Innovative Strategy for Enhancing Medication Delivery in Children and Elderly Patient

  • Unique Paper ID: 182006
  • Volume: 12
  • Issue: 2
  • PageNo: 455-461
  • Abstract:
  • Fast-dissolving tablets (FDTs) offer a patient-friendly dosage form, especially beneficial for pediatric and geriatric populations who often struggle with swallowing conventional tablets. This study aims to formulate and evaluate FDTs containing salbutamol sulphate, a bronchodilator, and cetirizine hydrochloride, an antihistamine, to facilitate rapid onset of action and improve patient compliance. Various superdisintegrants and excipients were screened to optimize tablet properties. The prepared tablets were evaluated for weight uniformity, hardness, friability, disintegration time, drug content, dissolution profile, and stability. Results demonstrated that the optimized formulation rapidly disintegrated within 30 seconds and exhibited satisfactory mechanical strength and drug release, highlighting its potential for improved drug delivery in target populations.

Copyright & License

Copyright © 2025 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{182006,
        author = {Ms. Priyanka Anil Ahire and Krupa Abhijit Khadakban and Ms. Nida Ali and Dr. Ganesh Bhagawat Giri and Mr. Amit Sureshrao Sontakke and Ms. Prajita Jivan Tayade},
        title = {Formulation and Evaluation of Fast-Dissolving Tablets Incorporating Salbutamol Sulphate and Cetirizine Hydrochloride: An Innovative Strategy for Enhancing Medication Delivery in Children and Elderly Patient},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {2},
        pages = {455-461},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=182006},
        abstract = {Fast-dissolving tablets (FDTs) offer a patient-friendly dosage form, especially beneficial for pediatric and geriatric populations who often struggle with swallowing conventional tablets. This study aims to formulate and evaluate FDTs containing salbutamol sulphate, a bronchodilator, and cetirizine hydrochloride, an antihistamine, to facilitate rapid onset of action and improve patient compliance. Various superdisintegrants and excipients were screened to optimize tablet properties. The prepared tablets were evaluated for weight uniformity, hardness, friability, disintegration time, drug content, dissolution profile, and stability. Results demonstrated that the optimized formulation rapidly disintegrated within 30 seconds and exhibited satisfactory mechanical strength and drug release, highlighting its potential for improved drug delivery in target populations.},
        keywords = {Fast-dissolving tablets, Salbutamol sulphate, Cetirizine hydrochloride, Pediatric drug delivery, Geriatric drug delivery, Superdisintegrants, Patient compliance.},
        month = {July},
        }

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