Neuropharmacology of psychedelics: potential treatments for mental health disorders

Pratiksha Bhaiyyasaheb Patil; Dhondge priya shivshankar; Disha rajkumar songara; Kiran Govardhan Naik; Sanket raghunath pawar; Mrs. Mrunali Shubham Palav

Neuropharmacology of psychedelics: potential treatments for mental health disorders

Authors: Pratiksha Bhaiyyasaheb Patil, Dhondge priya shivshankar, Disha rajkumar songara, Kiran Govardhan Naik, Sanket raghunath pawar, Mrs. Mrunali Shubham Palav

Unique Paper ID: 167716
Volume: 11
Issue: 4
PageNo: 142-147

Keywords: Psychedelics Neuropharmacology Mental Health Disorders Psilocybin MDMA Serotonin 5-HT2A receptors Neuroplasticity Major Depressive Disorder (MDD) Treatment-Resistant Depression (TRD) Anxiety Disorders

Abstract:
The resurgence of interest in psychedelics, including substances such as psilocybin, LSD, and DMT, has led to a significant re-evaluation of their therapeutic potential in the treatment of various mental health disorders. This review explores the neuropharmacology of psychedelics, focusing on their mechanisms of action, particularly their interactions with the serotonin 5-HT2A receptor, and the subsequent effects on neural circuits involved in mood, perception, and cognition. Psychedelics induce profound alterations in consciousness, which are hypothesized to facilitate therapeutic outcomes by disrupting maladaptive neural patterns and enhancing neuroplasticity. Emerging clinical studies suggest that psychedelics may be effective in treating conditions such as depression, anxiety, PTSD, and addiction, often demonstrating rapid and sustained improvements following limited dosing. Despite these promising results, the precise mechanisms underlying these effects remain incompletely understood, and there are significant challenges to be addressed, including dose standardization, patient selection, and the integration of these treatments into existing therapeutic frameworks. This abstract highlights the potential of psychedelics as a transformative approach in mental health treatment, while also acknowledging the need for continued research to fully understand their efficacy and safety

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Cite This Article

ISSN: 2349-6002
Volume: 11
Issue: 4
PageNo: 142-147

Neuropharmacology of psychedelics: potential treatments for mental health disorders

Available:https://ijirt.org/Article?manuscript=167716

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