Advancements in Drug Discovery: The Role of Combinatorial Chemistry and High-Throughput Screening

Ms.Ruchi Rohit Bhuran; Ms. Desale Roshani; Mr. Akshay Uttareshwar Landge; Ms.Poonam kasar; Mr. Rahul Shivaji Adnaik; Ms.Divya Vishwas Patil

Advancements in Drug Discovery: The Role of Combinatorial Chemistry and High-Throughput Screening

Authors: Ms.Ruchi Rohit Bhuran, Ms. Desale Roshani, Mr. Akshay Uttareshwar Landge, Ms.Poonam kasar, Mr. Rahul Shivaji Adnaik, Ms.Divya Vishwas Patil

Unique Paper ID: 167718
Volume: 11
Issue: 4
PageNo: 148-157

Keywords: Combinatorial Chemistry Combinatorial Library Drug Discovery High-Throughput Screening Computer-Assisted Drug Design One-Bead One-Compound Library DNA-Encoded Chemical Library

Abstract:
Combinatorial chemistry and high-throughput screening (HTS) are transformative techniques in drug discovery, enabling the rapid synthesis and evaluation of large libraries of chemical compounds. Combinatorial chemistry allows for the generation of diverse chemical libraries by systematically combining sets of building blocks to create a vast array of potential drug candidates. This method significantly accelerates the drug discovery process by producing numerous analogues of a lead compound for biological evaluation. High-throughput screening complements combinatorial chemistry by automating the testing of these large compound libraries against biological targets, such as proteins or enzymes. HTS utilizes advanced robotic systems, miniaturized assays, and sensitive detection methods to evaluate thousands to millions of compounds in a relatively short period. This approach identifies active compounds, or "hits," that exhibit desired biological activity, which can then be optimized through further chemical modifications. Together, combinatorial chemistry and high-throughput screening have revolutionized the early stages of drug development, increasing the efficiency of identifying novel therapeutic agents. These techniques reduce the time and cost associated with traditional drug discovery methods, allowing for the rapid identification of promising drug candidates and facilitating the development of new treatments for various diseases.

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ISSN: 2349-6002
Volume: 11
Issue: 4
PageNo: 148-157

Advancements in Drug Discovery: The Role of Combinatorial Chemistry and High-Throughput Screening

Available:https://ijirt.org/Article?manuscript=167718

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