NEXT-GENERATION HUMAN CELL CULTURE MODELS: REVOLUTIONIZING DRUG DISCOVERY AND SAFETY ASSESSMENT

Ms.Manisha G Suryavanshi; Ms. Monali Moreshwar Sawarbandhe; Mrs.Prerana Sachin Bhavsar; Prof. Sanjana Sanjay Bangar; Ms. Snehal Trimbak Daud; Mrs. Advika Anant Arolkar

NEXT-GENERATION HUMAN CELL CULTURE MODELS: REVOLUTIONIZING DRUG DISCOVERY AND SAFETY ASSESSMENT

Authors: Ms.Manisha G Suryavanshi, Ms. Monali Moreshwar Sawarbandhe, Mrs.Prerana Sachin Bhavsar, Prof. Sanjana Sanjay Bangar, Ms. Snehal Trimbak Daud, Mrs. Advika Anant Arolkar

Unique Paper ID: 170320
Volume: 11
Issue: 7
PageNo: 190-195

Keywords: Human Cell Culture Models 3D Cell Culture Organs-on-Chip Stem Cell-Based Models Drug Discovery Drug Screening Safety Assessment Toxicity Testing Personalized Medicine Disease Modeling High-Throughput Screening Microphysiological Systems iPSC Models Drug Efficacy Pharmaceutical Research Organ-on-Chip Technology Advanced Cell Culture Systems Humanized Models Regenerative Medicine Drug Toxicity Prediction Biomedical Engineering

Abstract:
The evolution of human cell culture models has significantly advanced drug discovery and safety assessment, providing more accurate and reliable alternatives to traditional in vivo methods. This review explores the impact of next-generation cell culture systems, including 3D cell cultures, organ-on-chip platforms, and stem cell-based models, in revolutionizing pharmaceutical research. These innovative models better replicate human physiology, disease states, and tissue complexity, offering superior predictive power for drug efficacy and toxicity. By enhancing drug screening, target identification, and personalized medicine approaches, these models facilitate more precise and ethically sound evaluations. Furthermore, their application in safety assessments has improved the detection of human-specific toxicities, reducing reliance on animal testing. Despite challenges such as high costs, complexity, and standardization issues, the integration of advanced technologies, such as artificial intelligence, promises to accelerate their development and regulatory acceptance. Looking forward, multi-organ models and improved tissue engineering techniques are expected to further refine human disease modeling, enabling more efficient drug discovery and personalized therapeutic strategies. This review underscores the transformative potential of next-generation human cell culture models in reshaping the future of drug development and safety assessment.

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ISSN: 2349-6002
Volume: 11
Issue: 7
PageNo: 190-195

NEXT-GENERATION HUMAN CELL CULTURE MODELS: REVOLUTIONIZING DRUG DISCOVERY AND SAFETY ASSESSMENT

Available:https://ijirt.org/Article?manuscript=170320

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