Copyright © 2025 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{170320,
        author = {Ms.Manisha G Suryavanshi and Ms. Monali Moreshwar Sawarbandhe and Mrs.Prerana Sachin Bhavsar and Prof. Sanjana Sanjay Bangar and Ms. Snehal Trimbak Daud and Mrs. Advika Anant Arolkar},
        title = {NEXT-GENERATION HUMAN CELL CULTURE MODELS: REVOLUTIONIZING DRUG DISCOVERY AND SAFETY ASSESSMENT},
        journal = {International Journal of Innovative Research in Technology},
        year = {2024},
        volume = {11},
        number = {7},
        pages = {190-195},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=170320},
        abstract = {The evolution of human cell culture models has significantly advanced drug discovery and safety assessment, providing more accurate and reliable alternatives to traditional in vivo methods. This review explores the impact of next-generation cell culture systems, including 3D cell cultures, organ-on-chip platforms, and stem cell-based models, in revolutionizing pharmaceutical research. These innovative models better replicate human physiology, disease states, and tissue complexity, offering superior predictive power for drug efficacy and toxicity. By enhancing drug screening, target identification, and personalized medicine approaches, these models facilitate more precise and ethically sound evaluations. Furthermore, their application in safety assessments has improved the detection of human-specific toxicities, reducing reliance on animal testing. 

Despite challenges such as high costs, complexity, and standardization issues, the integration of advanced technologies, such as artificial intelligence, promises to accelerate their development and regulatory acceptance. Looking forward, multi-organ models and improved tissue engineering techniques are expected to further refine human disease modeling, enabling more efficient drug discovery and personalized therapeutic strategies. This review underscores the transformative potential of next-generation human cell culture models in reshaping the future of drug development and safety assessment.},
        keywords = {Human Cell Culture Models,  3D Cell Culture, Organs-on-Chip, Stem Cell-Based Models, Drug Discovery, Drug Screening, Safety Assessment, Toxicity Testing, Personalized Medicine, Disease Modeling, High-Throughput Screening, Microphysiological Systems, iPSC Models, Drug Efficacy,  Pharmaceutical Research, Organ-on-Chip Technology, Advanced Cell Culture Systems, Humanized Models, Regenerative Medicine, Drug Toxicity Prediction, Biomedical Engineering},
        month = {December},
        }