IMPACT OF ANTIBIOTICS ON HUMAN GUT MICROBIOTA: SHORT- AND LONG-TERM EFFECTS

Hemangi Jagdish Baviskar; Tanuja bharat patil; Vishal Ramrao Panchal; Sanket balabhau pathrikar; Ankita Dattatray Patil; Narendra Jijabarao Patil

IMPACT OF ANTIBIOTICS ON HUMAN GUT MICROBIOTA: SHORT- AND LONG-TERM EFFECTS

Authors: Hemangi Jagdish Baviskar, Tanuja bharat patil, Vishal Ramrao Panchal, Sanket balabhau pathrikar, Ankita Dattatray Patil, Narendra Jijabarao Patil

Unique Paper ID: 171790
Volume: 11
Issue: 8
PageNo: 1100-1105

Keywords: No Keywords Found

Abstract:
Antibiotics are critical in combating bacterial infections but can significantly impact the human gut microbiota. This review explores the short- and long-term effects of antibiotic use on the microbial ecosystem of the gut. In the short term, antibiotics cause a rapid decline in bacterial diversity, disrupt the balance of commensal and pathogenic species, and may lead to overgrowth of opportunistic pathogens, such as Clostridioides difficile. Long-term effects include incomplete recovery of microbial diversity, lasting shifts in microbial composition, and potential links to chronic diseases such as obesity, diabetes, and inflammatory bowel disorders. The mechanisms underlying these disruptions include selective bacterial killing, altered metabolic pathways, and changes in gut immune interactions. Strategies for mitigating these effects, such as the use of probiotics, prebiotics, and fecal microbiota transplantation, are discussed. Understanding the complex interplay between antibiotics and gut microbiota is crucial for optimizing therapeutic interventions while preserving gut health.

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Cite This Article

ISSN: 2349-6002
Volume: 11
Issue: 8
PageNo: 1100-1105

IMPACT OF ANTIBIOTICS ON HUMAN GUT MICROBIOTA: SHORT- AND LONG-TERM EFFECTS

Available:https://ijirt.org/Article?manuscript=171790

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