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@article{153817,
        author = {Dr. Ramakrishna Gowda},
        title = {Comparative study of the crystal structure of 4-bromomethylcoumarins with different groups in the benzene ring},
        journal = {International Journal of Innovative Research in Technology},
        year = {},
        volume = {6},
        number = {10},
        pages = {406-409},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=153817},
        abstract = {4-Bromomethylcoumarins  were first reported by Dey and co-workers by the reaction of various phenols  and 4-bromoethylacetoacetate under Pechmann cyclisation conditions .Compounds  have been used for the synthesis of a variety of ethers, amines, sulphides, bi- and tri-heterocycles which have been screened for anti-microbials, anti-inflammatory and analgesic activities Halomethylcoumarins were screened for their protease inhibiting property and due to the biochemical importance of 7-methoxy-4-bromomethylcoumarin is now commercially available. FT-IR-Raman spectral studies along with ab-initio calculations have indicated the existence of conformers which differ in their orientation with respect to the coumarin ring.  
It is likely that the allylic bromine (with respect to C3-C4 double bond) is oriented an angle of around 100o to the mean plane of the coumarin moiety. 
In view of this, it was thought of considerable interest to study the X-ray structures of various 4-bromomethylcoumarins with different groups in the benzene ring. 
},
        keywords = {bromomethylcoumarin, Methoxy crystal x-ray study, Molecular Packing and hydrogen bonding},
        month = {},
        }