Review on the Synthesis and characterization of N-5{Acridin-9yl)-2-chloro phenyl}alkyl]aryl amides/imides possessing Antimicrobial activity

  • Unique Paper ID: 154330
  • Volume: 8
  • Issue: 10
  • PageNo: 551-555
  • Abstract:
  • An equivalent mixture of Diphenylamine and 4-chloro benzoic acid was heated in the presence of anhydrous ZnCl2 in ethanol. After few hours crude was extracted with benzene, then boiled with charcoal, filtered to get 9-(4-chlorophenyl)-acridine crystal (I). A finally powdered mixture of (I) and an appropriate amido/ imido alkylol (II) was dissolved in concentrated sulphuric acid which furnished N-[5-acridin-9-yl)-2-chlorophenyl}alkyl]-aryl amides/imides(III). Compound (III) were screened for their antimalarial activity involving the standardized method as recommended by National Committee on Clinical Laboratory Standards (NCCLS).

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Copyright © 2025 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{154330,
        author = {RENU SINGH},
        title = {Review on the Synthesis and characterization of N-5{Acridin-9yl)-2-chloro phenyl}alkyl]aryl amides/imides possessing  Antimicrobial activity},
        journal = {International Journal of Innovative Research in Technology},
        year = {},
        volume = {8},
        number = {10},
        pages = {551-555},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=154330},
        abstract = {An equivalent mixture of Diphenylamine and 4-chloro benzoic acid was heated in the presence of anhydrous ZnCl2 in ethanol. After few hours crude was extracted with benzene, then boiled with charcoal, filtered to get 9-(4-chlorophenyl)-acridine crystal (I). A finally powdered mixture of (I) and an appropriate amido/ imido alkylol (II) was dissolved in concentrated sulphuric acid which furnished N-[5-acridin-9-yl)-2-chlorophenyl}alkyl]-aryl amides/imides(III). Compound (III) were screened for their antimalarial activity involving the standardized method as recommended by National Committee on Clinical Laboratory Standards (NCCLS).},
        keywords = {Acridine derivatives, Animal charcoal, diphenyl derivatives.},
        month = {},
        }

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